Clinical trials are essential for advancing treatments for sarcoidosis, especially since no cure currently exists. With the cause of sarcoidosis still unknown, ongoing research remains critical to understanding and combating the disease.
Simbec-Orion is a Clinical Research Organisation specialising in rare diseases and oncology, with almost five decades of experience in delivering clinical trial management services. This article delves into the contributions of clinical trials to the understanding and treatment of sarcoidosis, while also emphasising the significance of Sarcoidosis Awareness Month in increasing public awareness of the condition.
What is Sarcoidosis?
Sarcoidosis is a rare disease characterised by the formation of small clusters of swollen tissue (known as granulomas) in various organs of the body. While it most commonly impacts the lungs and lymph nodes, it can also affect the skin.
The exact cause of sarcoidosis is unknown, but it is thought to involve both genetic and environmental factors. Experts believe the condition arises when the body’s immune system reacts to an unknown substance, leading to inflammation.
Sarcoidosis can affect people of any age, however it tends to start in adults aged between 30 and 40, and is very rare in childhood. It can affect people from all ethnic backgrounds, but it is more common in women. Most experts agree that around 1 in 10,000 people have sarcoidosis in the UK.
What are the Symptoms of Sarcoidosis?
The symptoms of sarcoidosis will depend on which organs are impacted, but according to the UK NHS, they typically include:
- Shortness of breath
- A persistent cough
- Tender bumps on the skin
For many people, symptoms of sarcoidosis improve on their own within a few months or years, and are typically not severe. However, for others, symptoms may gradually worsen over time, potentially affecting overall health. This more persistent form of the disease is known as chronic sarcoidosis.
Lung Symptoms
The lungs are affected in around 9 out of 10 people, which is known as pulmonary sarcoidosis. The main symptoms include shortness of breath and a persistent dry cough. In some rare cases, those affected may also experience pain and discomfort in their chest.
Skin Symptoms
If the skin is affected by sarcoidosis, it can cause tender bumps or patches to develop. This can occur particularly on the lower legs and arms, alongside bumps on the upper body, and are a reddish-brown or purple colour.
Sarcoidosis Awareness Month
Sarcoidosis Awareness Month is held each year in April, and aims to increase understanding of the disease and remind those affected that they are not alone in their journey.
Established in 2008 by the Foundation for Sarcoidosis Research (FSR), this month highlights the need for ongoing research and greater awareness of sarcoidosis.
How to Participate in Sarcoidosis Awareness Month
There are multiple ways you can get involved in Sarcoidosis Awareness Month, including:
- Sharing personal experiences – Sharing personal experiences is one of the most impactful ways for others to learn about sarcoidosis. These stories provide valuable insights, helping others understand the disease and learn how they can support ongoing research and those affected by it.
- Attending events – There are various educational and wellness programs throughout the month, allowing individuals to connect with members in the sarcoidosis community.
- Fundraising – There are opportunities to support organisations through fundraising efforts or by making direct donations.
The Importance of Clinical Trials for Sarcoidosis
Clinical trials are essential for discovering new and improved treatments, paving the way for innovative medical advancements. Sarcoidosis is a complex disease that can significantly impact quality of life, health, and work capacity. Many patients rely on long-term steroid treatment, which improves lung function but may cause side effects such as diabetes and bone disease. Some clinical trials are now aiming to develop new therapies to reduce dependence on steroids.
Clinical trials are conducted under strict regulations designed to protect participants and to ensure that any drug in development is not released for patient use until it has been proven safe and effective.
The trials progress through multiple phases – Phase I, Phase II, and Phase III. Each phase has a specific purpose and builds on the findings of the previous one to assess the safety, effectiveness, and optimal dosing of the treatment before it can be approved for widespread use.
Clinical Trials at Simbec-Orion
At Simbec-Orion, we provide comprehensive clinical trial management services across various therapeutic areas and phases. Our flexible, specialised approach has earned us a reputation as a trusted partner for our clients.
We have over almost 50 yearsof expertise in CRO services, collaborating with global clients to efficiently manage clinical trials, acting as a vital extension of their teams. To learn more about our services, reach out to us through the contact form.