

Simbec-Orion is a responsive and agile full-service CRO, delivering studies from first in man through to Phase III. Our experts leverage wide therapeutic experience and specialist expertise to execute a comprehensive portfolio of trials. We are perfectly structured to provide full-service clinical development solutions for small and mid-size drug developers , headed up by a centralised leadership team.
With a focus on tailor-made and scalable solutions, we’ll adapt our delivery style, communications and operations to suit the demands of your project, helping you achieve your clinical and commercial objectives. Because our goal is the same as yours; to improve patients’ lives.
Our Values
Our company culture is defined by our values: caring ambitiously, tight-knit teams, dedicated to delivery, forward-thinking, and radically honest.
Our Mission
Our passion for improving patients’ lives motivates us to apply our skills, experience and knowledge to advance medicine. We achieve this through flexible, innovative, high-quality solutions for our clients, delivered with integrity.
Stable teams
At the heart of Simbec-Orion is an exceptional team of professionals who embody our core values and are passionate about everything we do. With a shared commitment to excellence, our people make a meaningful impact on the lives of patients and drive drug development forward.
Our people bring our values to life every day, driving our success as a specialist Clinical Research Organisation. Together, we are dedicated to transforming the future of healthcare and improving the lives of patients around the world.
Many of our colleagues have spent much of their careers with us. With an attrition rate of under 10%, we are proud to share that over 14% of our colleagues have been with Simbec-Orion for over 10 years, and 22% have a tenure of 5-10 years. Our two longest-serving colleagues have been with us for more than 40 years! You can meet one of them, Deborah Evans, Clinic Manager at our Phase I Unit here.
Developing therapies for rare disease
Cost efficient trial design
The clinical development of orphan drugs represents a very interesting challenge that demands thoughtful and innovative designs. Orphan Drug clinical developers must become serious reliable players in the orphan space to attract investors and motivate all the stakeholders

Therapy Areas
in Detail
The clinical research organisation with wide therapeutic experience, specialising in rare disease and oncology clinical development solutions.
Financial and regulatory
advantages of conducting early phase clinical research studies
Simbec-Orion with the Department for International Trade (DIT) hosted an expert panel discussion to examine the financial and regulatory advantages for the US companies conducting Early Phase research in the UK.

Our clinical
development solutions
We support clients with a range of functional and full-service clinical development solutions. Our wide range of clinical services include clinical trial management, clinical pharmacology, central laboratory support, and more – all customised to your project’s specific needs. Find out more about our clinical development services.
Clinical Pharmacology
As a full-service facility, we carry out all types of studies at our purpose-built site. 90% of our work is with Investigational Medicinal Products, in all drug delivery routes.
Clinical pharmacology is a key part of our CRO services, so if you need support managing a clinical trial, there are many ways our expertise can help.
Clinical Trial Management Services
Our expert biometrics team delivers accurate and adaptive clinical data management services that support the success of your drug development programme.
Conducting statistical analysis, planning, and reporting across all clinical phases, they will create a quality biostatistical framework that presents clinical trial data clearly and correctly for regulatory agencies.
Central Laboratory Services
We are a CRO with in-depth experience in the most challenging therapeutic areas, including oncology, rare and orphan diseases, respiratory, dermatology, vaccines and anti-infectives.
With more than 25 years’ experience in the clinical research sector, we offer a comprehensive service you can trust – with an international reach. All with the highest level of quality, agility, and responsive customer service.
A full-service agile CRO
for complex clinical studies
For the last four decades, we have been providing clinical trial management services across a wide range of therapeutic indications and phases. Our passion is rare diseases and oncology.
Our experience defines our expertise
Responding to the needs of our clients has made us the CRO we are today; a partner, offering full-service clinical development with the size, agility and structure to respond rapidly when needed.
From Phase I clinical pharmacology studies through to Phase III rescue studies and post-marketing, we are here to take on the challenge – whatever the indication or compound you are passionate about, wherever you are in your clinical development journey.

What our
Clients Say About Us
The people working at Simbec Orion are dedicated, very professional and they cover all aspects of clinical research. A team will be set up for your project, who will have a strong focus on your study in a very open minded and friendly atmosphere. The studies I have outsourced to Simbec Orion, have been successfully managed and performed. I will use Simbec Orion in the future and I can strongly recommend them to other pharmaceutical companies.
Tina Lidén Mascher, Head of Clinical Operations
Klaria AB