Clinical trials are essential in advancing treatments for multiple sclerosis (MS). With no cure currently available, ongoing research is critical to uncovering new, more effective therapies.
Simbec-Orion is a Clinical Research Organisation with nearly five decades of experience, specialising in oncology and rare diseases. This article explores the vital role that clinical trials play in advancing the understanding and treatment of MS, while also highlighting the importance of World MS Day in raising public awareness about the condition. Through ongoing research and collaboration, clinical trials are essential in uncovering new insights and developing effective therapies for those affected by MS.
What is MS?
MS is a condition that affects the brain and spinal cord. It is caused because the immune system attacks myelin, which is the protective sheath surrounding nerve fibres. This then disrupts communication between the brain and the rest of the body. Over time, the disease can lead to permanent damage to the nerve fibres.
It is estimated that over 150,000 people in the UK are living with multiple sclerosis (MS), with nearly 7,100 new diagnoses occurring each year. You may be more likely to get MS if you’re aged 20-40, have a close relative with the disease, or you smoke.
What are the Symptoms of MS?
There are various symptoms associated with MS, some of which include:
- Fatigue
- Numbness in various parts of the body
- Tingling sensations
- Muscle cramps, stiffness and spasms
- Eye issues such as blurred vision or pain
- Memory and concentration problems
- Issues with bladder control
- Sexual problems
Types of MS
There are three main types of MS, classified based on symptom progression and the frequency of relapses. Each type can impact individuals differently.
Relapsing-remitting MS
Relapsing-remitting multiple sclerosis (RRMS) is the most common type of MS. It is characterised by periods of new symptoms or relapses that develop over days or weeks and typically improve, either partially or completely. These relapses are followed by periods of remission, during which the disease remains inactive, lasting for months or even years. Over time, RRMS often develops into secondary progressive MS.
Secondary-progressive MS
Secondary progressive multiple sclerosis (SPMS) is when symptoms persist continuously and gradually worsen over time. Relapses (where symptoms temporarily worsen and then improve) are less likely to occur with SPMS. The rate of disease progression in SPMS can vary significantly from person to person.
Primary-progressive MS
Primary progressive multiple sclerosis (PPMS) is less common than the other types of MS. Individuals with PPMS experience a gradual onset and steady progression of symptoms, with no relapses or periods of remission.
How MS Can Affect Everyday Life
As outlined above, MS can affect people differently. For some, the condition may have a minimal impact on daily life, while others may face much more severe symptoms. Since MS often impacts mobility, some individuals might need to adapt by using mobility aids or seeking additional support with tasks around the home.
World MS Day 2025
World MS Day is observed each year on the 30th May, aiming to raise awareness about multiple sclerosis and unite individuals living with the condition to share their stories and experiences.
History of World Ms Day
The first World MS Day took place in 2009, and was organised by the MS International Federation (MSIF). Since then, the campaign has reached hundreds of thousands of people worldwide, focusing on different themes each year. Each campaign is developed in collaboration with an international working group of member representatives, coming from the US, Greece, Argentina, Australia, India, Kenya, Tunisia, Spain, and the UK.
How to Get Involved in World MS Day
- Advocate for change – World MS Day serves as a platform to capture the attention of decision-makers, aiming to improve the lives of those living with multiple sclerosis.
- Participate in activities – You can get involved by organising activities such as fundraisers, conferences, or workshops to support World MS Day.
- Share stories – Raise awareness by sharing real stories and highlighting key issues related to MS. You can write an article, post a blog, or share on social media to spread the message.
How Clinical Trials Advance MS
Clinical trials provide valuable insights into the progression of MS and help identify potential treatments that could improve the quality of life for those living with the condition.
Clinical trials are the most reliable way to determine whether a new treatment is more effective than existing options. While a treatment may show promise in laboratory tests, its benefits and risks remain uncertain until evaluated through clinical trials. Given the significant variability of MS from one individual to another, these trials must involve numerous participants over an extended period to account for these differences and ensure accurate results.
Therefore, continued investment in clinical research is key to the fight against MS, bringing us closer to both a cure and improved treatment options to better manage the condition.
Clinical Trials at Simbec-Orion
Simbec-Orion delivers comprehensive clinical trial management services across a range of therapeutic areas and phases. Our adaptable and specialised approach has established us as a trusted partner for all our clients.
With nearly 50 years of expertise in CRO services, we collaborate with global clients to efficiently manage clinical trials, integrating as an extension of their teams. To learn more about our services, contact us through our online form.