Author: seoworks_web

In this series, we will be speaking with Simbec-Orion staff and asking them about their day-to-day work, what it involves and how they see their role developing in the future. In our first post, we are meeting Dr Maria Kozlak, a Clinical Research Associate (CRA) at Simbec-Orion. We’ll take a look at a day in…

Cancer research is one of the most commonly investigated areas of clinical study. Oncology research has accelerated the development of advanced chemotherapy drugs, which are now generally less toxic as a result. Conventional chemotherapy drugs once primarily used cytotoxic compounds to target cancerous cells, which would also damage surrounding cells as a result.  Now, with…

Clinical research is a broad area of patient care that investigates diseases, diagnostic methods and treatments, and plays a crucial role in progressing medical solutions to improve global health. This helps develop medical knowledge of how to identify, prevent, treat and manage health conditions. The importance that clinical research has on the development of medical…

Translational research takes scientific findings from more basic patient settings and translates these into insights that are used to develop treatment options. In essence, translational research establishes a bridge between basic research and clinical practice.   Translational research has become increasingly popular in biomedical sciences over recent years, particularly in the field of oncology.  This approach…

During phase 1 clinical trials, it is essential to establish safe and recommended dosages of the study drug or treatment. To determine this, dose escalation methods are used to examine the most tolerable dosage of the drug in patients early on in the trial. Read about the stages of clinical trials. The objective of dose…

On this International Women’s Day, we look at some of the ways in which the environment for women in the workplace has changed in the last five years. Firstly, there has been slow but positive progress in gender diversity in senior leadership roles over that time.  In 2018, the proportion of senior roles held by…

Urea Cycle Disorders are a group of inherited diseases that causes a deficiency in one of the enzymes involved in the urea cycle.  Each sub-type of the disorder group is named after the particular enzyme that is deficient. The urea cycle converts the nitrogen which is a waste product of protein metabolism into ammonia in…

Idiopathic Pulmonary Fibrosis (IPF) has an estimated prevalence of 13 to 20 per 100,000 people worldwide* and is a condition that typically affects people between the age of 50 and 70.  It is rarely seen in those under 50 years of age.  Symptoms of the condition develop gradually and can include a persistent dry cough,…

More than 70,000 children and adults are affected by Cystic Fibrosis (CF) worldwide.*  Cystic Fibrosis is a progressive, inherited disease which causes the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein to become dysfunctional.  This results in the protein being unable to move chloride to the cell surface with the consequence that the cell is then…

Many thousands of new drugs are developed every year. Before these can be administered by doctors and hospitals, they must undergo a thorough development and testing process. Drug development (also known as pharmaceutical product development) is a lengthy process, involving several important steps to ensure the drug is effective, safe and beneficial. It takes several…